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INDEX OF ARTICLES WAITING ROOM EXAM ROOM SURGERY ROOM X-RAY ROOM GENERAL TOPICS IMPORTANT TOPICS LAB and PHARMACY PET PHOTOS PET SUPPLIES PET PHARMACY
Canine Influenza (Canine Flu) may be a serious health hazard for dogs. CANINE INFLUENZA (Canine Flu)

A Newly Emerging Viral Infection Of Dogs

How To Test For Canine Influenza

Summarized by T. J. Dunn, DVM
Director, ThePetCenter.com

Canine Influenza (Canine Flu) may require veterinary medical intervention.

AUGUST, 2006
According to DVMNews.com the canine influenza outbreak has now been confirmed in 22 states.  New preliminary data suggests an infection rate of 16%.  [That means of 100 dogs exposed to the virus, 16 will actually show clinical signs of fever, coughing, lethargy, poor appetite and respiratory distress such as sneezing and coughing. TJD]  The mortality rate in the study suggests a higher mortality rate than previous reports.  This new study suggests a mortality rate of  7%.  [That means of 100 dogs actually showing signs of the disease, 7 will likely not survive it. TJD]

Canine Influenza, also called Canine Flu, is a  newly identified disease of dogs.  It can infect any breed of dog and appears in dogs to be similar to Canine Cough (also Only a small percent of Canine Influenza (Canine Flu) cases result in fatal outcomes.called Kennel Cough or Infectious Canine Tracheobronchitis).  However, early studies of Canine InfluenzaCanine Flu is not the same as canine Infectious Tracheobronchitis (a.k.a. Kennel Cough).indicate that the disease has adapted in the dog from a common infection in horses.  It is a highly contagious and sometimes deadly canine flu that is spreading in kennels and at dog tracks around the country.  It has been reported in Greyhounds at tracks in Florida, Iowa, Massachusetts, Arizona, West Virginia, Wisconsin, and Texas.

NOTE From Dr. Dunn at ThePetCenter.com...Currently there seems to be as much hysteria and misinformation about this emerging infection in dogs as hard scientific evidence.  Rumors of hundreds of dogs being affected in kennels across the country are unsubstantiated.  The best source of information about your local area regarding the facts about Canine Influenza will be your local veterinarian and your state's veterinary medical association.  The information presented on this page is meant to be strictly that... an update on recent information.  Your veterinarian must be consulted for proper diagnosis, patient evaluation, and individualized therapy for any disease or disorder your dog may have acquired.  There are a multitude of disorders and diseases that will cause a dog to cough and gag and hack.  That's why individual assessment for your dog is imperative to discern the true cause of the dog's difficulties.

How Is It Spread:  According to immunologist Dr. Cynda Crawford who is studying the virus at the University of Florida, College of Veterinary Medicine, it spreads most easily where numbers of dogs are kept in close proximity but could also be passed "on the street" or in kennels.  It has been reported that kennel workers have carried the virus home with them and infected other dogs.  The fatality rate seems to be between 1 and 10 percent.  Since it is such a new disease of dogs is difficult to forecast about the spread of the disease, severity in individual dogs, and what future numbers of cases may be seen .  Dr. Crawford indicates about 80 percent of dogs that are exposed to the canine influenza virus will develop some signs of illness.  Because the dog population has such little natural immunity to this virus, potentially every dog exposed could be infected.

Dr. Crawford first began investigating greyhound deaths in January 2004 at a racetrack in Jacksonville, Fla., where 8 of the 24 greyhounds who contracted the virus died. "This is a newly emerging pathogen," she said, "and we have very little information to make predictions about it. But I think the fatality rate is between 1 and 10 percent.  Canine Influenza is a respiratory viral infection.Because dogs had no natural immunity to the virus, virtually every animal exposed would be infected. About 80 percent of dogs that are infected with the virus will develop symptoms", Dr. Crawford said. She added that the symptoms were often mistaken for "kennel cough," a common canine illness that is caused by the bordetella bronchiseptica bacteria. Both diseases can cause coughing and gagging for up to three weeks, but dogs with canine flu may spike fevers as high as 106 degrees and have runny noses. A few will develop pneumonia, and some of those cases will be fatal. Antibiotics and fluid cut the pneumonia fatality rate.

The virus is an H3N8 flu which is related to an equine flu strain, however, it is not related to typical human flus or to the H5N1 avian flu that killed about 100 people in Asia. So far there are no known cases of the canine flu infecting humans. "The risk of that is low, but we are keeping an eye on it," said Dr. Ruben Donis, chief of molecular genetics for the influenza branch of the Centers for Disease Control and Prevention, which is tracking the illness. But with the approach of the human flu season and fears about bird flu in Asia, there is much confusion among some dog owners who have heard about the disease.  Dr. Crawford said she was fielding calls from kennels and veterinarians across the country worried that they were having outbreaks.

Signs Of Canine Influenza:  The signs in an infected dog are similar to Bordetella bronchiseptica bacterial infection commonly called Kennel Cough, Canine Cough and Infectious Canine Tracheobronchitis. Coughing and gagging for up to three weeks is seen in Canine Cough and in the newly emerging canine disease Canine Influenza. In-hospital treatment may be needed for Canine Influenza. Fevers as high as 106° can occur.  Increased signs of cough may be triggered by exercise or excitement.  Nasal discharge may be evident, as well.  The dog may act much quieter than usual or seem depressed and display a disinterest in its environment.

Treatment For Canine Influenza:  Keep in mind that viruses are not usually affected by antibiotics used against bacterial infections.  Antiviral drugs such as amantidine and Tamiflu have been used but are not licensed for use in dogs... the information base on the success of antiviral therapy is still small. Antibiotics for both Gram negative and Gram positive organisms may be needed due to secondary invasion of damaged lung tissues from opportunistic bacteria.  Fluid therapy for debilitated dogs could be required to give support to these patients while their own bodies create defensive immune factors to assist in warding off the infection.  Older dogs and young puppies may be at greatest risk for treatment failure.  X-rays may be needed to evaluate the severity of pneumonia.  In spite of vigorous in-hospital therapy, some dogs simply will not respond and will succumb to the disease.

Tests For Canine Influenza:
Veterinarians can send blood samples to the Cornell School of Veterinary Medicine, Animal Health Diagnostic Center, which is the only laboratory doing blood tests on Canine Influenza at this time.  Nasal swabs may be submitted to a veterinary pathologist for evaluation and virus isolation but the sample must be taken very early in the course of the infection... usually within 72 hours after signs develop in the dog.  Any dog that displays a persistent coughing, hacking or gagging A blood test can be taken to identify Canine Influenza.should be evaluated by a veterinarian.  Coughing, hacking or gagging are actually non-specific signs and therefore cannot be used to identify any single cause.  Do not assume your dog has Canine Influenza just because it is showing signs of a respiratory disorder.  These signs may be due to a variety of disorders such as tonsillitis, fungal disease such as Blastomycosis, Congestive Heart Failure, Heartworms, tumors, infiltrative immune disorders of the bronchial structures, foreign body obstruction and other disorders.  A diagnostic workup may be needed to positively identify the cause of the dog's difficulty.  Ask your veterinarian about vaccinating your dog against the Bordetella organism that is associated with Infectious Tracheobronchitis (Kennel Cough), the common and familiar respiratory disorder affecting unprotected dogs.  Will a vaccine be developed for this new and emerging disease of dogs called Canine Influenza (Canine Flu)?  Scientists are already studying this disease and the chances of immunization being a reality are assured if this infection continues to spread.  Contact your veterinarian for more information.

More about... TESTS FOR CANINE FLU (INFLUENZA)

Below is a message sent to Wisconsin veterinarians by the Wisconsin Veterinary Medical Association.  It contained a message from Christopher W. Olsen, DVM PhD at the School of Veterinary Medicine, Madison, WI.  Dr. Olsen's email is below.  Note that for virus isolation and identification to be accurate, the nasal swab must be taken from the dog within a short time of displaying signs of Canine Influenza.  After the 72 hours of clinical signs, recovery of live virus from the dog is unlikely and at that point serological (blood) testing may be helpful in making a diagnosis of the disease.


"While there is no vaccine available yet to protect dogs from influenza virus infection, diagnostic tests are available; both virus isolation and serology can be done through the Wisconsin Veterinary Diagnostic Laboratory (WVDL) in Madison.
 
My recommendation is that if practitioners are presented with dogs within the first 72 hours of illness, they should obtain separate swab samples (using Dacron, not cotton, swabs) of the nasal passages and pharyngeal region for virus isolation, and they should collect a serum sample, to be followed by a second "convalescent" sample about 3 weeks later.  Virus isolation sample kits can be requested from the WVDL, and specific testing and sample shipping information will soon be posted on the WVDL website (www.wvdl.wisc.edu) or can be obtained by calling the lab at (608) 262-5432.  If a practitioner is presented with a dog after 10-14 days of coughing, then just a single serum sample is appropriate, and attempts at virus isolation beyond the initial 72 hours of illness are not useful because dogs are likely to only shed virus for a short period of time.  As to the specific serologic test, both hemagglutination-inhibition and virus neutralization tests have been developed and both are useful."
Christopher W. Olsen, DVM PhD
Professor of Public Health
Department of Pathobiological Sciences
School of Veterinary Medicine
University of Wisconsin-Madison
 
 
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