Slentrol... The First Weight Control Drug (Medication) For Obese Dogs From Pfizer, Inc.

FDA News

FOR IMMEDIATE RELEASE
P07-01
January 5, 2007

Media Inquiries: 
Michael Herndon, 301-827-6242
Consumer Inquiries: 
888-INFO-FDA

The Food and Drug Administration (FDA) today is announcing the approval of Slentrol (dirlotapide), a prescription drug for the management of obesity in dogs. Slentrol reduces appetite and fat absorption to produce weight loss. A veterinarian will determine whether the dog should be treated, based on the dog's weight and general health.

"This is a welcome addition to animal therapies, because dog obesity appears to be increasing," said Stephen Sundlof, D.V.M., Ph.D., director of FDA's Center for Veterinary Medicine. "Veterinarians are well aware that overweight pets are at a higher risk of developing various health problems, from cardiovascular conditions to diabetes to joint problems."

Veterinarians generally define a dog that weighs 20 percent more than its ideal weight as obese. Surveys have found that approximately 5 percent of dogs in the United States are obese, and another 20-30 percent are overweight.

Slentrol is a new chemical entity, called a selective microsomal triglyceride transfer protein inhibitor, which blocks the assembly and release of lipoproteins into the bloodstream. The mechanism for producing weight loss is not completely understood, but seems to result from reduced fat absorption and a satiety signal from lipid-filled cells lining the intestine.

The drug is given to the dog in varying amounts over the course of the treatment. The dog is given an initial dose for the first 14 days. After that, the veterinarian will assess the dog's progress at monthly intervals, adjusting the dose depending on the dog's weight loss. After the dog has achieved the goal weight, the drug's manufacturer recommends continued use of the drug during a three-month period, while the veterinarian and dog owner establish the optimal level of food intake and physical activity needed to maintain the dog's weight.

Adverse reactions associated with treatment with Slentrol include vomiting, loose stools, diarrhea, lethargy and loss of appetite.

To discourage human use, the label of Slentrol includes the standard warning, "Not for use in humans. Keep this and all drugs out of reach of children," and cites adverse reactions associated with human use, including abdominal distention, abdominal pain, diarrhea, flatulence, headache, nausea and vomiting.
Slentrol is manufactured by Pfizer Inc., New York, N.Y.

Ask your veterinarian about this new medication for dogs that may be an important part of a total life style that promotes proper body weight. Every dog or cat with a weight control problem needs veterinary attention so that individualized medical tests can be done to discover any medical problem that could contribute to the dog or cat's body weight issues.

Healthy dogs and cats thrive on exercise, high quality pet foods based on meat protein (not corn), and individualized amounts fed per meal. Consider feeding less of a high quality diet (to reduce the total calories fed) rather than large amounts of "lite" or "low fat" or "reduced calorie" pet foods.